Therapy with a severe acute respiratory syndrome- associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden syrian hamsters
Identifieur interne : 004405 ( Main/Exploration ); précédent : 004404; suivant : 004406Therapy with a severe acute respiratory syndrome- associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden syrian hamsters
Auteurs : Anjeanette Roberts [États-Unis] ; William D. Thomas [États-Unis] ; Jeannette Guarner [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Gregory J. Babcock [États-Unis] ; Thomas C. Greenough [États-Unis] ; Leatrice Vogel [États-Unis] ; Norman Hayes [États-Unis] ; John L. Sullivan [États-Unis] ; Sherif Zaki [États-Unis] ; Kanta Subbarao [États-Unis] ; Donna M. Ambrosino [États-Unis]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (administration et posologie), Anticorps antiviraux (sang), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (usage thérapeutique), Charge virale, Cricetinae, Femelle, Immunoglobuline G (sang), Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Pneumopathies interstitielles (anatomopathologie), Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- administration et posologie : Anticorps antiviraux, Anticorps monoclonaux.
- anatomopathologie : Pneumopathies interstitielles, Poumon.
- immunologie : Virus du SRAS.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- sang : Anticorps antiviraux, Immunoglobuline G.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Animaux, Charge virale, Coronavirus, Cricetinae, Femelle, Homme, Hamster, Immunothérapie, Mesocricetus, Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère, Tests de neutralisation, Traitement, Anticorps neutralisant, Anticorps monoclonal, Microbiologie, Infection, Syndrome respiratoire aigu sévère.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (administration & dosage), Antibodies, Viral (blood), Antibodies, Viral (therapeutic use), Coronavirus, Cricetinae, Disease Models, Animal, Female, Hamster, Human, Immunoglobulin G (blood), Immunotherapy, Infection, Lung (pathology), Lung (virology), Lung Diseases, Interstitial (pathology), Mesocricetus, Microbiology, Monoclonal antibody, Neutralization Tests, Neutralizing antibody, SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Treatment, Viral Load.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antibodies, Viral.
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- pathology : Lung, Lung Diseases, Interstitial.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Cricetinae, Disease Models, Animal, Female, Immunotherapy, Mesocricetus, Neutralization Tests, Viral Load.
Abstract
Background. Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. Methods. Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. Results. Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 102.4-103.9 50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. Conclusions. The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.
Affiliations:
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Le document en format XML
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Thomas</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</wicri:noRegion></affiliation></author><author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Babcock, Gregory J" sort="Babcock, Gregory J" uniqKey="Babcock G" first="Gregory J." last="Babcock">Gregory J. Babcock</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</wicri:noRegion></affiliation></author><author><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C." last="Greenough">Thomas C. Greenough</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Pediatrics and Molecular Medicine, University of Massachusetts Medical School</s1><s2>Worcester</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Worcester</wicri:noRegion></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hayes, Norman" sort="Hayes, Norman" uniqKey="Hayes N" first="Norman" last="Hayes">Norman Hayes</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Pediatrics and Molecular Medicine, University of Massachusetts Medical School</s1><s2>Worcester</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Worcester</wicri:noRegion></affiliation></author><author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ambrosino, Donna M" sort="Ambrosino, Donna M" uniqKey="Ambrosino D" first="Donna M." last="Ambrosino">Donna M. Ambrosino</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Massachusetts Biologic Laboratories, University of Massachusetts Medical School, Jamaica Plain</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (administration & dosage)</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antibodies, Viral (administration & dosage)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (therapeutic use)</term><term>Coronavirus</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Female</term><term>Hamster</term><term>Human</term><term>Immunoglobulin G (blood)</term><term>Immunotherapy</term><term>Infection</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Lung Diseases, Interstitial (pathology)</term><term>Mesocricetus</term><term>Microbiology</term><term>Monoclonal antibody</term><term>Neutralization Tests</term><term>Neutralizing antibody</term><term>SARS Virus (immunology)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Treatment</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (administration et posologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps antiviraux (usage thérapeutique)</term><term>Anticorps monoclonaux (administration et posologie)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Charge virale</term><term>Cricetinae</term><term>Femelle</term><term>Immunoglobuline G (sang)</term><term>Immunothérapie</term><term>Mesocricetus</term><term>Modèles animaux de maladie humaine</term><term>Pneumopathies interstitielles (anatomopathologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Tests de neutralisation</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Pneumopathies interstitielles</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Lung Diseases, Interstitial</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Female</term><term>Immunotherapy</term><term>Mesocricetus</term><term>Neutralization Tests</term><term>Viral Load</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Coronavirus</term><term>Cricetinae</term><term>Femelle</term><term>Homme</term><term>Hamster</term><term>Immunothérapie</term><term>Mesocricetus</term><term>Modèles animaux de maladie humaine</term><term>Syndrome respiratoire aigu sévère</term><term>Tests de neutralisation</term><term>Traitement</term><term>Anticorps neutralisant</term><term>Anticorps monoclonal</term><term>Microbiologie</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. Methods. Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. Results. Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 10<sup>2.4</sup>-10<sup>3.9</sup> 50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. Conclusions. The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name></region><name sortKey="Ambrosino, Donna M" sort="Ambrosino, Donna M" uniqKey="Ambrosino D" first="Donna M." last="Ambrosino">Donna M. Ambrosino</name><name sortKey="Babcock, Gregory J" sort="Babcock, Gregory J" uniqKey="Babcock G" first="Gregory J." last="Babcock">Gregory J. Babcock</name><name sortKey="Greenough, Thomas C" sort="Greenough, Thomas C" uniqKey="Greenough T" first="Thomas C." last="Greenough">Thomas C. Greenough</name><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><name sortKey="Hayes, Norman" sort="Hayes, Norman" uniqKey="Hayes N" first="Norman" last="Hayes">Norman Hayes</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Sullivan, John L" sort="Sullivan, John L" uniqKey="Sullivan J" first="John L." last="Sullivan">John L. Sullivan</name><name sortKey="Thomas, William D" sort="Thomas, William D" uniqKey="Thomas W" first="William D." last="Thomas">William D. Thomas</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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